The First Clinical Experience of Implantation of the Xenopericardial Bioprosthesis “MEDENG-BIO” with the “Easy Change” System

Konstantin Petlin, Boris Kozlov, Anton Schedrin, Andrey Pryakhin, Dmitry Panfilov, Vladimir Shipulin

Cardiology Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

Date, time and location: 2018.05.25 13:30, Exhibition area, 1st Floor. Zone – D

Abstract

Methods.From October 2016 to November 2017, the aortic valve prosthesis “MEDENG-BIO” was implanted in 41 patients (mean age 67.77 ± 3.42 years) at the clinics of the Cardiology Research Institute of the Tomsk NRMC. The aortic valve defects of degenerative etiology predominated (34 patients 83%), which led to prevalence of stenosis (31 patients 76%) and a combination of stenosis and regurgitation (8 patients 20%).

In coronary angiography, 12 patients had hemodynamically significant atherosclerotic lesions of the coronary arteries, coronary artery bypass grafting was performed. In 4 patients, mitral valve interventions were additionally performed, in 8 patients reconstructive intervention on the ascending aorta was performed (predominantly ascending aorta prosthesis as Hemiarch type), in 1 patient aortic root plasty according to Manugian.

Results.The mean duration of cardiopulmonary bypass with isolated aortic valve replacement was 89.7 ± 16.64 min, with combined operations it was 130.67 ± 31.4 min. The mean aortic cross-clamp time with isolated aortic valve replacement was 69.1 ± 12.54 min, whereas in combined operations it was 106.4 ± 27.5 min.

Control echocardiography in the hospital period revealed an improvement in intracardiac hemodynamics. The mean pressure gradient on the aortic valve in patients with initial stenosis decreased more than 2-fold (up to 43% from preoperative). After 6-12 months, an increase in the mean gradient on the prosthesis was not observed. In addition, there is a decrease in the volume of the left ventricle, a decrease in the calculated mass of the myocardium and a tendency to decrease the thickness of the wall of the left ventricle.

Conclusion. Thus, the first experience with the use of the aortic bioprosthesis “MEDENG-BIO” demonstrated a satisfactory result on follow up to 12 months. To create final and statistically significant conclusions, further material accumulation is necessary.